Ultrasound (Sonography) uses high-frequency sound waves; these waves are produced and transmitted to the body by a device placed on the abdomen. A softener gel is applied to the body for a more complete wave transfer to the body. The waves pass through the tissues after entering the body and travel from one organ to another and then are bounced off to the body surface. Ultrasound device receives these waves which are used to take images of internal organs. Movement observation is also possible in ultrasound, so fetal movements or its internal organs can be detected and examined. In weeks 5 to 6 of pregnancy, fetal heart rate is visible as well. Pregnancy ultrasound is used to diagnose the health of the fetus in the mother’s uterus and is normally performed four times as recommended by a gynecologist. All these measurements are carried out to determine the exact age of the fetus and the risk of disease which must be reported by an accurate ultrasound. According to specialists, women are better to have an ultrasound of the uterus and ovaries prior to planning to conceive to get informed about their fertility status. Ultrasound helps the physician to know about the health of the uterus (in terms of size or presence of abnormalities), the presence of apolipo fibroids or ovarian cyst, and many other uterine problems; however, in case of the need for treatment and follow up measures, the patient receives necessary instructions from her doctor.

Bepotastine besilate is a selective histamine H1-receptor antagonist and a second-generation non-sedating antihistamine approved for relief from pruritis in various dermatological disorders. Aim: To study the real world efficacy and tolerance of bepotastine in cutaneous disorders associated with pruritus and other symptoms (redness, wheal and angioedema), by assessing patient’s perceived symptomatic improvement. 

Aim: To study the real world efficacy and tolerance of bepotastine in cutaneous disorders associated with pruritus and other symptoms (redness, wheal and angioedema), by assessing patient’s perceived symptomatic improvement. 
Methodology: Adult patients presenting clinically with any of the symptoms: pruritis, redness, wheal or angioedema, associated with skin conditions, were evaluated to record patient’s end of treatment perception of improvement in the presenting symptoms, as well as tolerance to treatment, in response to bepotastine 10mg twice a day. Adverse events if any were recorded, assessed and managed. 
Results: Overall for each symptom, complete or significant relief was obtained by >80% patients (P<0.001). Average treatment duration was 21 days or less in 80% patients. Patients achieving complete relief was maximum between 14-21 days. The adverse event rate was low at 0.3%0.
Conclusion: Bepotastine 20mg/day, is an effective and well tolerated treatment for improving pruritis and other symptoms: erythema, wheal and angioedema, associated with cutaneous disorders, with an optimum treatment duration of 14-21 days.

Introduction: Internet addiction is one of the addictive behaviors and typically described as a state where an individual has lost control of the internet use and keeps using internet excessively to the point where he/she experiences problematic outcomes that negatively affects life. Objective: The aim of this study was to assess the magnitude and associated factor of internet addiction among regular under graduate students at Haramaya University, College of Health and Medical Science, from July1, 2021 to December 1, 2021. Method: Institutional based cross-sectional study was conducted in Haramaya University College of Health and Medical Sciences. The total of 216 under graduate students was enrolled in this study. The simple random sampling methods were employed to collect the representative samples. Internet Addiction was measured byYoung’s Internet Addiction test (YIAT). Logistic regression model were used to evaluate the association between IA and associated factors. P-value andadjusted odds ratio within 95 % level of confidence (CI) was used to interpret the results. Result from total of 216 study participants the overall magnitude of internet addiction among under graduate Haramaya University College of Health and Medical Sciences students was 57.9%. Factors such as current Khat use [AOR =1.94, 95% CI (1.05, 3.56)] and having psychological distress [AOR =1.15, 95% CI (1.032, 3.407)] were found to be significantly associated with magnitude of internet addiction. Conclusion The currentstudy shows that fifty seven percentof undergraduate students in Haramaya University were addicted to the internet. So internet addiction was associated with using current Khat user and having psychological. Therefore we recommended students need to be educated about safe, valuable, and healthy practice of internet use and better to counsel on substance use and its consequences to overcome the anticipated increase in internet addiction.

Schwannomas are the most common mediastinal neurogenictumors; they are usually benign and slow growing and frequentlyarise from a spinal nerve root, but may involve any thoracicnerve

Macrophage stimulating protein (MSP) was discovered as a serum protein affecting macrophage motility, and found to be similar with a hepatocyte growth factor (HGF)-family molecule, HGF-liked protein (HLP). MSP/HLP has 45% sequence similarity with HGF. Inactive pro-MSP is synthesized by hepatocytes and released into the circulating blood, and its activation is regulated in disease pathologies such as in inflammation and cancer progression. Through binding to the RON receptor, MSP acts in innate- immune responses and anti- inflammation, and prevents the induction of iNOS, COX-2, and PGE2 in response to endotoxin and interferon-
crucial regulator of inflammation in multiple animal disease models of the liver, kidney, lung, gut and other organs. Also, MSP suppresses glucose production and negatively regulates the expression of gluconeogenic enzymes. HGF-Met and MSP-Ron signaling have analogous functions. In future, MSP/RON signaling becomes a new important drug target, especially for excess inflammation, and the inhibition of Ron inhibitors is expected for cancer therapy.