The aim of this review was to analyze cardiovascular risks on hematopoietic stem cell transplant (HSCT) among adults. Studies were extracted on PubMED as the database. Medical Subject Heading (MeSH) were entered as key words using Boolean operators “AND” and “OR” to widen the number of hits. The final numbers of hits were 135 identified records from PubMed search engine. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline was used to eliminate other studies. A-132 eliminated studies were due to the use of non-human subjects, non-experimental studies, and studies focusing only on women totaling to 3 studies left. Regardless of the variables that affected the findings, it was still concluded that the cardiovascular system was at risk. Both allogeneic and autologous HSCTs were more likely to cause an alteration in left ventricular ejection fraction rate, decreasing the stroke volume, heart rate variability and heart turbulence, increase in blood pressure, cardiac decompensation, and heart failure.